Cholera

From a local disease, cholera became one of the most widespread and deadly diseases of the 19th century, killing an estimated tens of millions of people. In Russia alone, between 1847 and 1851, it is estimated that the death toll exceeded one million. In the United States, there were 150,000 cholera deaths during the second pandemic. In the two decades between 1900 and 1920, perhaps eight million Indians died of cholera.